HYPERTELORISM

- INCREASED INTERORBITAL DISTANCE

In early development the eyes are placed laterally in the primitive face and migrate towards the midline as gestation progresses. Hypertelorism is an increased interorbital distance and this can be either an isolated finding or associated with many clinical syndromes or malformations. The most common syndromes with hypertelorism are the median cleft syndrome.

1. Frontonasal dysplasia (median cleft syndrome).
2. Frontal, ethmoidal or sphenoidal meningoencephalocele.
3. Megalencephaly.
4. Associations.
• Aperts syndrome.
• Cloverleaf skull.
• Craniosynostosis.
• Opitz (BBB) syndrome.
• Larsen's syndrome.
• Orodigito-Facial Syndrome.
• Restrictive dermopathy.
• Achondroplasia.
• Lethal multiple pterygium syndrome.
• Arthrogryposis multiplex congenita.

Hypertelorism