ANOMALIES ASSOCIATED WITH

DANDY-WALKER MALFORMATION

MENDELIAN

• Walker-Warburg Syndrome (AR)
• Aase-Smith Syndrome (AD)
• Ruvalcaba Syndrome (AD/X-linked).
• Coffin-Siris Syndrome (AR).
• Orofaciodigital Syndrome type II (AR)
• Meckel-Gruber Syndrome (AR).
• Aicardi's Syndrome (X-linked dominant).
• Ellis-van Creveld Syndrome (AR).
• Fraser crytophthalmos (AR).

CHROMOSOMAL

• 45,X 6p- 9q+ dup 5p, 8p, 8q, 17q
• Trisomy 9
• Triploidy

ENVIRONMENTAL

• Cytomegalovirus and Rubella.
• Coumadin
• Alcohol
• Diabetes
• Isotretinoin

MULTIFACTORIAL

• Congenital heart disease, neural tube defects and cleft lip/palate

SPORADIC

• Holoprosencephaly
• de Lange's Syndrome
• Goldenhar's Syndrome
• Kidney Abnormalities.
• Facial hemangiomas
• Klippel-Feil Syndrome
• Polysyndactyly