METABOLIC DISORDERS ASSOCIATED

WITH CALLOSAL AGENESIS

1. Non-ketotic hyperglycinemia (1,2).
2. Diabetes insipidus has been reported to be common in children with septo-optic dysplasia and/or with callosal agenesis.
3. Teratogens in fetal alcohol syndrome (1).
4. Possibly maternal ingestion of crack cocaine (3).

REFERENCES

1. Dobyns WB. Agenesis of the corpus callosum and gyral malformations are frequent manifestations of nonketotic hyperglycemia. Neurology 1989;39:817-820.
2. Bamforth F, Bamforth S, Poskett K et.al. Abnormalities of the corpus callosum in patients with inherited metabolic disease. Lancet 1988;2:451-452.
3. Dominguez R, Vila-Coro AA, Slopis JM, Bohan TP. Brain and ocular abnormalities in infants with in utero exposure to cocaine and other street drugs. Am J Dis Child 1991;145:688-695.