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CHOROID PLEXUS CYSTS
(CPC) |
CPC are fluid filled spaces within the choroid plexus.
CPC are thought to result from CSF entrapped in the developing neuroepithelial folds. Portions of the epithelium are pinched off and become either tubules or neuroepithelial lined cysts within the choroidal matrix.
There is a significant controversy in the literature regarding the appropriate counseling and obstetric management of pregnancies complicated by the incidental detection of fetal choroid plexus during routine scans. Initial reports (1) describe this entity as a normal variant and recommend a repeat ultrasound at 24 weeks to confirm disappearance of the cyst as sufficient in the management of these patients. This conservative approach was questioned in 1986, when Nicolaides and co-workers noted and association between choroid plexus cysts and aneuploidy, particularly trisomy 18. Thus arose the controversy as to whether fetal karyotyping should be offered when choroid plexus cysts are detected antenatally, and which parameter, if any, increases the risk of chromosomal aneuploidy.
1.
Embryology
2.
Ultrasound
3.
Table of reported frequency of aneuploidy
associated with CPC